Regarding the Hallmarks of Cancer , read the statements below.
I - The epidermal growth factor receptor (EGF-R/erbB) is upregulated in stomach, brain and breast tumors.
II - About half of the human colon carcinomas bear mutant ras oncogens.
III - The loss of function of the p53 tumor suppressor can facilitate both angiogenesis and resistance to apoptosis.
IV - Within a given cancer type, mutation of particular target genes such as ras or p53 may be found in only a subset of otherwise histollogically identical tumors.
Which statements are correct?
