De acordo com o CANMAT, 2016 (KENNEDY, Sidney H. et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. The Canadian Journal of Psychiatry, v. 61, n. 9, p. 540-560, 2016.), é considerado antidepressivo de 1ª linha no tratamento das depressões: